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Mike Griffin, Ph.D.
BiochemistryDepartment of Chemistry
One University Drive
Orange, CA 92866
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| Teaching |
General Chemistry CHEM 140, 150
Medicinal Chemistry CHEM 350
Biochemistry I: Biomolecules CHEM 335 (Lecture and Lab)
Biochemistry II: Biometabolism CHEM 336
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| Degrees |
University of California, San Francisco
Ph.D. 1983: Pharmacology and Toxicology
University of California, San Diego
BA 1976: Chemistry |
Current
Employment |
Researcher Step IV, Dept of Pharmacology UCI School of Medicine, 1990 – present
Professor, Department of Chemistry, Chapman University, Orange, 1987 - present |
| Research |
Role of Muscarinic Receptor Subtypes in Smooth Muscle Contraction
Expression of Muscarinic Receptors in Transfected Cells
Cell Membrane Signal Transduction
Neurotransmitter Receptor Mediated Effector Systems
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| Publications |
Ehlert, F.J., Ching-Hsuan, J., Leung, K., Lee, A.G., Scehnaz, D., and Griffin, M.T. (2005) Comparison of the Antimuscarinic Action of p-Fluorohexahydrosiladifenidol in Ileal and Tracheal Smooth Muscle. J. Pharmacol. Exp. Ther. 312: 592-600
Ehlert, F.J., Griffin, M.T., Abe, D.M., Vo, T.H., Taketo, M.M., Manabe, T., and Matsui, M. (2005) M2 Muscarinic Receptors Mediate Contraction through Indirect Mechanisms in Mouse Urinary Bladder. J. Pharmacol. Exp. Ther. 313: 368-378
Griffin, M.T., Figueroa, K.W., Liller, S., and Ehlert, F.J. (2007) Estimation of Agonist Activity at G Protein Coupled Receptors: Analysis of M2 Muscarinic Receptor Signaling thoughGi/0, Gs and G15. J. Pharmacol. Exp. Ther. 321: 1193-1207
Ehlert, F.J., and Griffin, M.T. (2008) Two-state models and the analysis of the allosteric effect of gallamine at the M2 muscarinic receptor. J. Pharmacol. Exp. Ther. 325(3): 1039-60 |
| Professional Associations |
Society for Neuroscience
American Association of University Professors |
| Awards, Grants and Fellowships |
Chapman University Scudder Award, 2001
Chapman Faculty Research Award, 2001, 1999, 1998, 1997, 1994, 1989, 1988
Co-Investigator National Institutes of Health Grant PHS-NIH Neurological Disorder and Stroke NS-30882
Title: Autonomic Muscarinic Receptor Signaling Mechanisms $644,725 1997-2001
Chapman University Excellence Award 1994
Co-Investigator National Institutes of Health Grant R01 NS-30882-01 $538,456 1992-96
Hua-Cheng Wang Fellowship 1991-1993
National Research Service Award T32 NS07166-05 1984-1985
National Research Service Award T32 GM07175-03-07 1979-1983
Earl C. Anthony Patent Fund Award 1982-1983
Pharmaceutical Manufacturers Association Foundation Award 1982 |
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