Dr. Maduka Ogba

Dr. Maduka Ogba

Assistant Professor
Schmid College of Science and Technology; Chemistry
Expertise: Computations; Organocatalysis; Organometallic chemistry; Catalyst design; Conformational analysis; Cheminformatics;
Office Location: Keck Center for Science and Engineering 232
Phone: (714) 516-5536
Website: http://www.theomolab.com
Education:
Trinity University, Bachelor of Science
Oregon State University, Ph.D.

Biography

In 2011, Professor O. Maduka Ogba earned his B.S. in computer science and minor in chemistry at Trinity University in San Antonio, Texas. While at Trinity, Prof. Ogba conducted research with Prof. Steven Bachrach in his computational organic chemistry group.  

In 2016, he was awarded his Ph.D. in chemistry at Oregon State University for work with Prof. Paul Ha-Yeon Cheong developing computational routines for investigating complex organocatalysis and reaction processes. From 2016 to 2018, Maduka conducted his Robbins Postdoctoral Fellowship at Pomona College, California working with Prof. Daniel J. O’Leary using computational NMR chemical shifts and isotope effects predictions to probe molecular structure, non-covalent interactions, and chemical transformations.

In 2018, Prof. Ogba joined Chapman University as an assistant professor of chemistry in Schmid College of Science and Technology. In this role, Prof. Ogba enjoys working with students in his computational chemistry research lab (The OMO Lab) to (i) study the underlying chemical interactions governing molecular structure, reaction mechanisms, and selectivity in chemical transformations, and to (ii) develop software and informatics tools for chemists to use to rapidly mine, analyze, and visualize chemical data. Prof. Ogba also enjoys teaching students fundamental theories in organic and computational chemistry.

 

On February 18, 2019, Dr. Ogba was a guest speaker for Schmid College's Science on Tap Series. 

 

 

Recent Creative, Scholarly Work and Publications

Kolahdouzan, K.; Ogba, O. M.; O’Leary, D. J. 1H NMR Studies of Intramolecular OH/OH Hydrogen Bonds via Titratable Isotope Shifts. J. Org. Chem. 2022, 87 (3), 1732–1744. https://doi.org/10.1021/acs.joc.1c01910.
Han, B.; Khasnavis, S. R.; Nwerem, M.; Bertagna, M.; Ball, N. D.; Ogba, O. M.* Calcium Bistriflimide-Mediated Sulfur(VI)–Fluoride Exchange (SuFEx): Mechanistic Insights toward Instigating Catalysis. Inorg. Chem. 2022, 61 (25), 9746–9755. https://doi.org/10.1021/acs.inorgchem.2c01230.
Elliott, S. J.; Ogba, O. M.; Brown, L. J.; O’Leary, D. J. An Examination of Factors Influencing Small Proton Chemical Shift Differences in Nitrogen-Substituted Monodeuterated Methyl Groups. Symmetry 2021, 13, 1610. https://doi.org/10.3390/sym13091610.
Perkins, A.; Tudorica, D. A.; Teixeira, R. D.; Schirmer, T.; Zumwalt, L.; Ogba, O. M.; Cassidy, C. K.; Stansfeld, P. J.; Guillemin, K. A Bacterial Inflammation Sensor Regulates C-Di-GMP Signaling, Adhesion, and Biofilm Formation. Mbio 2021, 12 (3), e00173-21. https://doi.org/10.1128/mbio.00173-21.
Liberman-Martin, A. L.; Ogba, O. M. Midsemester Transition to Remote Instruction in a Flipped College-Level Organic Chemistry Course. J. Chem. Educ. 2020, 97 (9), 3188–3193. https://doi.org/10.1021/acs.jchemed.0c00632.
Zumwalt, L.; Perkins, A.; Ogba, O. M. Mechanism and Chemoselectivity for HOCl-Mediated Oxidation of Zinc-Bound Thiolates. ChemPhysChem 2020, Just Accepted. https://doi.org/10.1002/cphc.202000634.
Kolahdouzan, K.; Ogba, O. M.; O’Leary, D. J. 1H and 13C NMR Assignments for (N-Methyl)-(-)-(a)-Isosparteinium Iodide and (N-Methyl)-(-)-Sparteinium Iodide. Magnetic Resonance in Chemistry 2019, 57 (1), 55–64. https://doi.org/10.1002/mrc.4792.
Ogba, O. M.; Liu, Z.; O’Leary, D. J. Vibrational Analysis of a Rate-Slowing Conformational Kinetic Isotope Effect. Tetrahedron 2019, 75 (5), 545–550. https://doi.org/10.1016/j.tet.2018.12.051.
Titaley, I. A.; Ogba, O. M.; Chibwe, L.; Hoh, E.; Cheong, P. H.-Y.; Simonich, S. L. M. Automating Data Analysis for Two-Dimensional Gas Chromatography/Time-of-Flight Mass Spectrometry Non-targeted Analysis of Comparative Samples. Journal of Chromatography A 2018, 1541, 57–62. https://doi.org/10.1016/j.chroma.2018.02.016.
Ogba, O. M.; Warner, N. C.; O’Leary, D. J.; Grubbs, R. H. Recent Advances in Ruthenium-Based Olefin Metathesis. Chem. Soc. Rev. 2018, 47 (12), 4510–4544. https://doi.org/10.1039/C8CS00027A.
Brueckner, A. C.; Ogba, O. M.; Snyder, K. M.; Richardson, H. C.; Cheong, P. H.-Y. Conformational Searching for Complex, Flexible Molecules. In Applied Theoretical Organic Chemistry; WORLD SCIENTIFIC (EUROPE), 2017; pp 147–164. https://doi.org/10.1142/9781786344090_0005.
Ogba, O. M.; Thoburn, J. D.; O'Leary, D. J. Spreadsheet-Based Computational Predictions of Isotope Effects. In Applied Theoretical Organic Chemistry; WORLD SCIENTIFIC (EUROPE), 2017; pp 403–450. https://doi.org/10.1142/9781786344090_0014.
Ogba, O. M.; Elliott, S. J.; Kolin, D. A.; Brown, L. J.; Cevallos, S.; Sawyer, S.; Levitt, M. H.; O’Leary, D. J. Origins of Small Proton Chemical Shift Differences in Monodeuterated Methyl Groups. J. Org. Chem. 2017, 82 (17), 8943–8949. https://doi.org/10.1021/acs.joc.7b01356.
Walden, D. M.; Ogba, O. M.; Johnston, R. C.; Cheong, P. H.-Y. Computational Insights into the Central Role of Nonbonding Interactions in Modern Covalent Organocatalysis. Acc. Chem. Res. 2016, 49 (6), 1279–1291. https://doi.org/10.1021/acs.accounts.6b00204.
Perkins, A.; Parsonage, D.; Nelson, K. J.; Ogba, O. M.; Cheong, P. H.-Y.; Poole, L. B.; Karplus, P. A. Peroxiredoxin Catalysis at Atomic Resolution. Structure 2016, 24 (10), 1668–1678. https://doi.org/10.1016/j.str.2016.07.012.
Gonzalez, J. A.; Ogba, O. M.; Morehouse, G. F.; Rosson, N.; Houk, K. N.; Leach, A. G.; Cheong, P. H.-Y.; Burke, M. D.; Lloyd-Jones, G. C. MIDA Boronates Are Hydrolysed Fast and Slow by Two Different Mechanisms. Nat Chem 2016, 8 (11), 1067–1075. https://doi.org/10.1038/nchem.2571.

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