Dr. Surya Nauli

Dr. Surya Nauli

Professor
School of Pharmacy
Expertise: Primary Cilium; Vascular Diseases; Polycystic; Kidney Diseases;
Office Location: Rinker Health Science Campus 272
Phone: (714) 516-5485
Scholarly Works:
Digital Commons
Education:
Minnesota State University-Mankato, Bachelor of Science
Loma Linda University, Ph.D.

Biography

Surya Nauli received his doctorate education in Pharmacology from Loma Linda Medical School.  He completed his NIH fellowship at Harvard Medical School followed by his appointment as an Instructor in Medicine.  He then joined the University of Toledo and was promoted to tenured Associate Professor.  In 2014, Dr. Nauli accepted a professor position in the Department of Biomedical & Pharmaceutical Sciences at Chapman University School of Pharmacy.  Specific areas currently under investigation in his laboratory include (1) molecular, cellular, and biophysical studies of primary cilia; (2) chemical screening for pharmacological candidates in vitro; and (3) development of a more efficient in vivo system to further characterize the cilia-targeting therapy in vascular and kidney diseases. 

For inquiry, please visit  http://sites.chapman.edu/nauli/

Research Interests 

Main Research Area includes:

  • Cilia Biology
  • Cardiovascular Disease
  • Polycystic Kidney Disease

Recent Creative, Scholarly Work and Publications

Sajid MI, Sheikhc FS, Anisd F, Nasime N, Sumbria RK, Nauli SM, and Tiwari RK. siRNA Drug Delivery Across Blood-Brain Barrier (BBB). Adv Drug Deliv Rev. 2023 Aug;199:114968.
Monfared RV, Abdelkarim S, Derdeyn P, Chen K, Wu H, Leong K, Chang T, Lee J, Versales S, Nauli S, Beier K, Baldi P, Alachkar A. Spatiotemporal Mapping of Brain Cilia Reveals Region-Specific Oscillation of Length and Orientation. bioRxiv. 2023 Jul 15:2023.06.28.546950.
Sajid MI, Nunez FJ, Amirrad F, Roosan MR, Vojtko T, McCulloch S, Alachkar A, Nauli SM*. Untargeted metabolomics analysis on kidney tissues from mice reveals potential hypoxia biomarkers. Sci Rep. 2023 Oct 16;13(1):17516.
Pala R, Barui AK, Mohieldin AM, Zhou J, Nauli SM*. Folate conjugated nanomedicines for selective inhibition of mTOR signaling in polycystic kidneys at clinically relevant doses. Biomaterials. 2023 Nov;13;302:122329.
Alhassen W, Kobayashi Y, Su J, Robbins B, Nguyen H, Myint T, Yu M, Nauli SM, Saito Y, Alachkar A. Regulation of Brain Primary Cilia Length by MCH Signaling: Evidence from Pharmacological, Genetic, Optogenetic, and Chemogenic Manipulations. Mol Neurobiol. 2022 Jan;59(1):245-265.
Amirrad F, Pala R, Shamloo K, Muntean BS, Nauli SM. Arrhythmogenic Hearts in PKD2 Mutant Mice Are Characterized by Cardiac Fibrosis, Systolic, and Diastolic Dysfunctions. Front Cardiovasc Med. 2021 Nov 26;8:772961.
Mohieldin AM, Alachkar A, Yates J, Nauli SM. Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer's associated proteins. Commun Integr Biol. 2021 Dec 25;14(1):264-269.
Puthenpurail A, Rathi H, Nauli SM, Ally A. A brief synopsis of monoclonal antibody for the treatment of various groups of diseases. World J Pharm Pharm Sci. 2021 Nov;10(11):14-22.
Tran N, Garcia T, Aniqa M, Ali S, Ally A, Nauli SM. Endothelial Nitric Oxide Synthase (eNOS) and the Cardiovascular System: in Physiology and in Disease States. Am J Biomed Sci Res. 2022;15(2):153-177.
Gupta A, Thirugnanam K, Thamilarasan M, Mohieldin AM, Zedan HT, Prabhudesai S, Griffin MR, Spearman AD, Pan A, Palecek SP, Yalcin HC, Nauli SM, Rarick KR, Zennadi R, Ramchandran R. Cilia proteins are biomarkers of altered flow in the vasculature. JCI Insight. 2022 Feb 10:e151813.
Alshammari QA, Pala R, Barui AK, Alshammari SO, Nauli AM, Katzir N, Mohieldin AM, Nauli SM. The use of advanced spectral imaging to reveal nanoparticle identity in biological samples. Nanoscale. 2022 Mar 17;14(11):4065-4072. [FEATURED IN THE FRONT PAGE JOURNAL]
Sarmah N, Nauli AM, Ally A, Nauli SM. Interactions among Endothelial Nitric Oxide Synthase, Cardiovascular System, and Nociception during Physiological and Pathophysiological States. Molecules. 2022 Apr 29;27(9):2835.
Thirugnanam K, Prabhudesai S, Van Why E, Pan A, Gupta A, Foreman K, Zennadi R, Rarick KR, Nauli SM, Palecek SP, Ramchandran R. Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability. Biochem Pharmacol. 2022 Jun 11;202:115143.
Nam YW, Pala R, El-Sayed NS, Larin-Henriquez D, Amirrad F, Yang G, Rahman MA, Orfali R, Downey M, Parang K, Nauli SM, Zhang M. Subtype-Selective Positive Modulation of KCa2.3 Channels Increases Cilia Length. ACS Chem Biol. 2022 Aug 19;17(8):2344-2354.
Amirrad F, Fishbein GA, Edwards RA, Nauli SM. Hypertrophic and fibrotic human PKD hearts are associated with macrophage infiltration and abnormal TGF-ß1 signaling. Cell Tissue Res. 2022 Nov 15.
Nam YW, Kong D, Wang D, Orfali R, Sherpa RT, Totonchy J, Nauli SM, Zhang M. Differential modulation of SK channel subtypes by phosphorylation. Cell Calcium. 2021 Mar;94:102346.
Alhassen W, Chen S, Vawter M, Robbins BK, Nguyen H, Myint TN, Saito Y, Schulmann A, Nauli SM, Civelli O, Baldi P, Alachkar A. Patterns of cilia gene dysregulations in major psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jul 13;109:110255.
Alshammari QA, Pala R, Katzir N, Nauli SM. Label-free spectral imaging to study drug distribution and metabolism in single living cells. Sci Rep. 2021 Feb 1;11(1):2703.
Pala R, Pattnaik S, Busi S, Nauli SM. Nanomaterials as Novel Cardiovascular Theranostics. Pharmaceutics. 2021 Mar 7;13(3):348.
Mohieldin AM, Pala R, Beuttler R, Moresco JJ, Yates JR 3rd, Nauli SM. Ciliary extracellular vesicles are distinct from the cytosolic extracellular vesicles. J Extracell Vesicles. 2021 Apr;10(6):e12086.
Chen S, Alhassen W, Vakil Monfared R, Vachirakorntong B, Nauli SM, Baldi P, Alachkar A. Dynamic Changes of Brain Cilia Transcriptomes across the Human Lifespan. Int J Mol Sci. 2021 Sep 27;22(19):10387.
Jamal MH, Nunes ACF, Vaziri ND, Ramchandran R, Bacallao RL, Nauli AM, Nauli SM. Rapamycin treatment correlates changes in primary cilia expression with cell cycle regulation in epithelial cells. Biochem Pharmacol. 2020 Aug;178:114056.
Pala R, Anju VT, Dyavaiah M, Busi S, Nauli SM. Nanoparticle-Mediated Drug Delivery for the Treatment of Cardiovascular Diseases. Int J Nanomedicine. 2020 May 27;15:3741-3769.
Ally A, Powell I, Ally MM, Chaitoff K, Nauli SM. Role of neuronal nitric oxide synthase on cardiovascular functions in physiological and pathophysiological states. Nitric Oxide. 2020 Sep 1;102:52-73.
Mohieldin AM, Pala R, Sherpa RT, Alanazi M, Alanazi A, Shamloo K, Ahsan A, AbouAlaiwi WA, Moresco JJ, Yates III JR, Nauli SM. Proteomic Identification Reveals the Role of Ciliary Extracellular-Like Vesicle in Cardiovascular Function. Adv Sci (Weinh). 2020; 7:1903140 [FEATURED IN THE FRONT PAGE JOURNAL]
Pala R, Mohieldin AM, Shamloo K, Sherpa RT, Kathem SH, Zhou J, Luan Z, Zheng JG, Ahsan A, Nauli SM. Personalized Nanotherapy by Specifically Targeting Cell Organelles To Improve Vascular Hypertension. Nano Lett. 2019 Feb 13;19(2):904-914
Pala R, Mohieldin AM, Sherpa RT, Kathem SH, Shamloo K, Luan Z, Zhou J, Zheng JG, Ahsan A, Nauli SM. Ciliotherapy: Remote Control of Primary Cilia Movement and Function by Magnetic Nanoparticles. ACS Nano. 2019 Mar 26;13(3):3555-3572.
Sherpa RT, Mohieldin AM, Pala R, Wachten D, Ostrom RS, Nauli SM. Sensory primary cilium is a responsive cAMP microdomain in renal epithelia. Sci Rep. 2019 Apr 25;9(1):6523.
Atkinson KF, Sherpa RT, and Nauli SM. The Role of the Primary Cilium in Sensing Extracellular pH. Cells. 2019, 8, 704: 1-20
Sherpa RT, Pala R, Mohieldin AM, Nauli SM. Measurement cytoplasmic and cilioplasmic calcium in a single living cell. Methods in Cell Biol. 2019;153:25-42.
Nauli SM. Cholesterol may not have a special place in kidneys. Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1169-F1170. [EDITORIAL]
Pala R, Jamal M, Alshammari Q, Nauli SM. The Roles of Primary Cilia in Cardiovascular Diseases. Cells. 2018 Nov 27;7(12). pii: E233. [FEATURED IN THE FRONT PAGE JOURNAL]
Pala R, Alomari N, Nauli SM. Primary Cilium-Dependent Signaling Mechanisms. Int J Mol Sci. 2017 Oct 28;18(11).
Omran AJA, Saternos HC, Althobaiti YS, Wisner A, Sari Y, Nauli SM, AbouAlaiwi WA. Alcohol consumption impairs the ependymal cilia motility in the brain ventricles. Sci Rep. 2017 Oct 20;7(1):13652.
Shamloo K, Chen J, Sardar J, Sherpa RT, Pala R, Atkinson KF, Pearce WJ, Zhang L, Nauli SM. Chronic Hypobaric Hypoxia Modulates Primary Cilia Differently in Adult and Fetal Ovine Kidneys. Front Physiol. 2017 Sep 20;8:677.
Atkinson KF, Nauli SM. pH sensors and ion Transporters: Potential therapeutic targets for acid-base disorders. International Journal of Pharma Research & Review. 2016 March 01; 5(3):51-58.
Kathem SH, AbouAlaiwi WA, Zi X, Nauli SM. Capillary Endothelia from Two ADPKD Patients are Polyploidy. Annals of clinical cytology and Pathology. 2016 April 25; 2(2):1022.
Grimes DT, Keynton JL, Buenavista MT, Jin X, Patel SH, Kyosuke S, Vibert J, Williams DJ, Hamada H, Hussain R, Nauli SM, Norris DP. Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination. PLoS Genet. 2016 Jun 6;12(6):e1006070.
Doerr N, Wang Y, Kipp KR, Liu G, Benza JJ, Pletnev V, Pavlov TS, Staruschenko A, Mohieldin AM, Takahashi M, Nauli SM, Weimbs T. Regulation of Polycystin-1 Function by Calmodulin Binding. PLoS One. 2016 Aug 25;11(8):e0161525.
Sherpa RT, Atkinson KF, Ferreira VP, Nauli SM. Rapamycin increases length and mechanosensory function of primary cilia in renal epithelial and vascular endothelial cells. Int Educ Res J. 2016 Dec;2(12):91-97.
Nauli SM, Pala R, Kleene SJ. Calcium channels in primary cilia. Curr Opin Nephrol Hypertens. 2016 Sep;25(5):452-8.
Mohieldin AM, Zubayer HS, Al Omran AJ, Saternos HC, Zarban A, Nauli SM, AbouAlaiwi WA. Vascular Endothelial Primary Cilia: Mechanosensation and Hypertension. Curr Hypertens Rev. 2016;12(1):57-67.
Aal-Aaboda M, Alhaddad H, Osowik F, Nauli SM, Sari Y. Effects of (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline on glutamate transporter 1 and cysteine/glutamate exchanger as well as ethanol drinking behavior in male, alcohol-preferring rats. J Neurosci Res. 2015 Jun;93(6):930-7.
Mohieldin AM, Haymour HS, Lo ST, AbouAlaiwi WA, Atkinson KF, Ward CJ, Gao M, Wessely O, Nauli SM. Protein composition and movements of membrane swellings associated with primary cilia. Cell Mol Life Sci. 2015 Jun;72(12):2415-29.
Patel S, Garapati C, Chowdhury P, Gupta H, Nesamony J, Nauli S, Boddu SH. Development and evaluation of dexamethasone nanomicelles with potential for treating posterior uveitis after topical application. J Ocul Pharmacol Ther. 2015 May;31(4):215-27.
Atkinson KF, Kathem SH, Jin X, Muntean BS, Abou-Alaiwi WA, Nauli AM, Nauli SM. Dopaminergic signaling within the primary cilia in the renovascular system. Front Physiol. 2015 Apr 16;6:103.
Al Omran AJ, Saternos HC, Liu T, Nauli SM, AbouAlaiwi WA. Live Imaging of the Ependymal Cilia in the Lateral Ventricles of the Mouse Brain. J Vis Exp. 2015 Jun 1;(100):e52853.
Mohieldin AM, AbouAlaiwi WA, Gao M, Nauli SM. Chemical-Free Technique to Study the Ultrastructure of Primary Cilium. Sci Rep. 2015 Nov 2;5:15982.
The cell’s antenna; sensory roles of primary cilia: ciliopathy and ciliotherapy. International Innovation. January 2015. Issue 170, page 98

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