» Dr. Gennady Verkhivker
Professor

Schmid College of Science and Technology
Physics, Computational Science and Engineering, School of Computational Sciences
Dr. Gennady Verkhivker
Phone:
714-516-4586
Email:
Website:
http://compbiosciences.chapman.edu/
Education
Lomonosov Moscow State University, Bachelor of Science
Lomonosov Moscow State University, Master of Science
Biography
Dr. Verkhivker is currently a Professor of Computational Biology. He is also an Adjunct Professor of Pharmacology at the Department of Pharmacology, UC San Diego. His research activities are in the areas of computational cancer biology, translational bioinformatics, and computational pharmacology. He received his PhD in Physical Chemistry from Moscow University and completed a postdoctoral fellowship in computational biophysics from University of Illinois at Chicago. In 2000-2005, Dr. Verkhivker has held various research and management positions at Pfizer Global Research and Development, San Diego.  Since 2002, he has been Adjunct Professor of Pharmacology at the Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego. In 2006, he joined School of Pharmacy and Center for Bioinformatics, The University of Kansas as a Professor of Pharmaceutical Chemistry and Bioinformatics. Dr. Verkhivker returned to California in 2011 and joined Chapman University in August 2011 as a Full Professor of Computational Biology. Upon arrival to Chapman, Dr. Verkhivker has established a dynamic research group engaged in translational research that attracted a large cohort of undergraduate and graduate students.  He has been involved in various global University initiatives and collaborations. Dr. Verkhivker has served on a number of important committees including Search Committee for new Found Dean of BioPharmacy School. He is also chairing the Doctoral Steering Committee of the newly approved PhD Graduate Program in Computational Sciences.
Recent Creative, Scholarly Work and Publications
Blacklock K, Verkhivker GM. Differential Modulation of Functional Dynamics and Allosteric Interactions in the Hsp90-Cochaperone Complexes with p23 and Aha1: A Computational Study. PLoS One. 2013 Aug 19;8(8):e71936. doi: 10.1371/journal.pone.0071936
Nathan Lawless 1, Kristin Blacklock 1, Elizabeth Berrigan and Gennady Verkhivker 1,2,* Structural Bioinformatics and Protein Docking Analysis of the Molecular Chaperone-Kinase Interactions: Towards Allosteric Inhibition of Protein Kinases by Targeting the Hsp90-Cdc37 Chaperone Machinery Pharmaceuticals 2013, 6, 1-x manuscripts; doi:10.3390/ph60x000x
Experimentally-Guided Structural Modeling and Dynamics Analysis of the Hsp90-p53 Interactions: Allosteric Regulation of the Hsp90 Chaperone by a Client Protein Kristin Blacklock, Gennady M. Verkhivker J Chem Inf Model. 2013
A. Dixit, G.Verkhivker Probing molecular mechanisms of the hsp90 chaperone: biophysical modeling identifies key regulators of functional dynamics. PLoS One. 2012;7(5):e37605. Epub 2012 May 18.
G Verkhivker. Simulating Molecular Mechanisms of the MDM2-Mediated Regulatory Interactions: A Conformational Selection Model of the MDM2 Lid Dynamics, Plos One 2012;7(7):e40897. Epub 2012 Jul 16
Dixit A, Verkhivker GM. Integrating ligand-based and protein-centric virtual screening of kinase inhibitors using ensembles of multiple protein kinase genes and conformations. J Chem Inf Model. 2012 Oct 22;52(10):2501-15. doi: 10.1021/ci3002638. Epub 2012 Oct 1.